The US Centers for Disease Control and Prevention (CDC) today warned clinicians and public health departments about reports of fatal Vibrio vulnificus infections from wound exposure to contaminated coastal waters or from eating raw or undercooked shellfish.

In a Health Alert Network notice, the CDC said V vulnificus usually thrives in warmer waters during the summer months, and infections have been most commonly reported in Gulf Coast states, but cases on the East Coast have risen eightfold and have expanded northward over roughly the past two decades. This summer, the United States has experienced above-average sea surface temperatures and multiple heat waves. Severe or fatal Vibrio infections have been reported in several East Coast states, including Connecticut, New York, and North Carolina.

Prompt treatment is crucial to reduce mortality from severe V. vulnificus infection.

In the face of increasing water temperature and extreme weather events linked to climate change, the CDC urged people who are at risk for Vibrio infections, including those with underlying health conditions, to use caution when engaging in coastal-water activities. It also urged healthcare providers to consider V vulnificus as a possible cause of infection in patients with wounds exposed to coastal waters.

Officials urged clinicians who suspect Vibrio infections to start early antibiotic or surgical treatment without waiting for lab confirmation or consultation with an infectious disease specialist. "Prompt treatment is crucial to reduce mortality from severe V. vulnificus infection."

A study of more than 285,000 nonhospitalized US veterans who tested positive for COVID-19 in 2022 and early 2023 reveals low rates of prescribing of antivirals and monoclonal antibodies (mAbs), with a higher likelihood of treatment for Black, Hispanic, and older patients with more chronic conditions.

For the study, published yesterday in JAMA Network Open, a Veterans Affairs (VA)-led research team mined Veterans Health Administration (VHA) and linked Community Care and Medicare databases on the number of prescriptions each month for the antiviral medications nirmatrelvir-ritonavir (Paxlovid), molnupiravir (Lagevrio) and the mAbs sotrovimab (Xevudy) and bebtelovimab from January 2022 through January 2023.

Median age of the 285,710 enrollees was 63.1 years, 86.6% were men, 69.6% were White, 21.4% were Black, and 10.0% were Hispanic.

84% received no COVID treatment

Of all COVID-19 patients, 9.3% were prescribed nirmatrelvir-ritonavir, 3.2% were given molnupiravir, 1.7% received sotrovimab or bebtelovimab, and 83.8% received no treatment. The remaining 2.0% received other COVID-19 drugs such as remdesivir (1.8%) or other monoclonal antibodies (0.3%) and weren't included in the any-treatment or no-treatment groups.

The proportion of veterans receiving any COVID-19 treatment rose from 3.2% in January 2022 to 23.9% in August 2022 and then fell to 20.8% in January 2023. Veterans most likely to receive any treatment were older (adjusted odds ratio [aOR] for ages 65 to 74 vs 50 to 64 years, 1.18) and had a higher Charlson Comorbidity Index (CCI) score (aOR for CCI score of 6 or higher vs 0, 1.52).

A more recent decline has not been widely reported in nonveteran populations.

Black veterans were more likely than their White peers to be prescribed a COVID-19 drug (aOR, 1.06), and Hispanic veterans had greater odds of receiving treatment than their non-Hispanic counterparts (aOR, 1.06).

"Although trends in early uptake of COVID-19 pharmacotherapies within the VHA mirrored other settings, a more recent decline has not been widely reported in nonveteran populations," the study authors wrote. "These results suggest the need for continued support of infrastructure and education to facilitate treatment for individuals at highest risk of progression to severe COVID-19."

The Wisconsin Department of Agriculture,​​​​ Trade and Consumer Protection (DATCP) yesterday confirmed that a deer on a deer farm in Washburn County has tested positive for chronic wasting disease (CWD).

A 3-year-old doe tested positive. The 150-acre farm has been placed under quarantine while DATCP and US Department of Agriculture scientists conduct an epidemiologic investigation. Washburn County is located in northwestern Wisconsin.

The samples were confirmed positive for CWD by the National Veterinary Services Laboratories in Ames, Iowa. CWD is an always-fatal neurologic disease of deer, elk, and moose caused by an infectious protein called a prion that affects the animal's brain and nervous system and leads to erratic behavior and muscle wasting. Public health officials fear it might one day cross into people, similar to bovine spongiform encephalitis, or "mad cow" disease.

The most recent previous farm to test positive in Wisconsin was in late May in Sauk County in the southwestern part of the state. DATCP data show that 9 deer farms in the state are still operating after a CWD detection, and 17 were shut down after deer tested positive.

Three countries in two regions reported new polio cases this week, all of them involving vaccine-derived viruses, the Global Polio Eradication Initiative (GPEI) said in its latest weekly update.

In Africa, Chad reported 4 cases involving circulating vaccine-derived poliovirus type 2 (cVDPV2), raising its total for the year to 29. The new infections were in Lac, Logone Oriental, and Logone Occidental regions.

Also, the Democratic Republic of the Congo reported 16 cVDPV2 cases, pushing its 2023 total to 81. The illnesses were mostly in Kasai Oriental province, but also in Tanganyika, Bas Uele, and Haut Lomami provinces. The country also reported 6 cases involving circulating vaccine-derived poliovirus type 1 (cVDPV1), bringing that total to 54 and the total of vaccine-derived cases to 135. Five of those cases were in Haut Katanga, and 1 was in Tanganyika.

In the Middle East, Yemen reported one cVDPV2 case, marking its first of the year. The patient is from Alhudiadah, and officials are planning a surveillance review to identify any gaps in case finding. Last year, Yemen reported 162 cVDPV2 cases.