Eight more measles cases have been reported, putting the nation's total at 121 so far this year, the US Centers for Disease Control and Prevention (CDC) said in its latest weekly update. The number of affected jurisdictions remained the same, at 18.

Of the 121 cases, 86 were linked to seven outbreaks, including a large one at a Chicago migrant shelter. Last year at this time the CDC had received reports of 58 cases, 28 of them linked to four outbreaks.

Of the cases this year, 47% occurred in children younger than 5 years old. Young children also had the highest level of hospitalizations (65%). And. of people infected, 82% were unvaccinated or had an unknown vaccination status.

LA County visitor was at Universal Studios

In related developments, the Los Angeles County Department of Public Health said state health officials have notified it of a measles case involving a resident from outside the county who had recently visited several locations in Los Angeles County, including Universal Studios.

The patient had also stayed at a hotel for 3 nights and visited several restaurants in the area. County health officials also said they are investigating more locations where exposure might have occurred. 

During this month's annual European Society of Clinical Microbiology and Infectious Diseases (ESCMID Global) conference in Spain, UK researchers will present evidence that patients successfully treated for tuberculosis (TB) have lasting lung damage, including smaller lungs with narrower airways and slower air flow.

The findings are based on a meta-analysis of data collected on 75,631 people from 15 studies conducted in 17 countries with varying TB incidence and income levels from 2000 through 2023. Of the 75,631 study participants, 7,377 were TB survivors.

Four measures of lung functions were included in the analysis: Forced expiratory volume in 1 second (FEV1, the volume of air that can be forcefully exhaled in one second); forced vital capacity (FVC, the volume of air that can be forcefully exhaled in a single breath); FEV1/FVC ratio; and FVC as a percentage of the predicted value (compares the volume to the average of a healthy person of the same age, sex, and height).

Lung injury poses public health challenge

"FEV1 was 230 millilitres lower compared to healthy controls, and FVC was 140 millilitres lower," said lead researcher Dr Sharenja Ratnakumar, of the University of London, in a press release from ESCMID Global. "A decrease in FEV1 of 100 millilitres is considered clinically significant and is associated with an increased risk of cardiovascular and respiratory disease."

While the treatment of acute TB has been the main clinical focus for the past several decades, the authors said it's time to recognize the toll of post-TB lung disease. Between 2000 and 2020, an estimated 74 million lives were saved after successful TB treatment, with many patients under the age of 50. The burden of post-TB lung damages is not yet known, the authors said, and likely poses a significant public health challenge. 

Our study also provides compelling evidence that the long-term care of individuals with post-tuberculosis lung disease should be an explicit component of the WHO's End TB strategy.

"Our study also provides compelling evidence that the long-term care of individuals with post-tuberculosis lung disease should be an explicit component of the WHO's End TB strategy," Ratnakumar said. 

In the 30 days after COVID-19 infection, total sperm count, sperm concentration, total sperm motility (movement), and progressive motility were significantly reduced in a cohort of Chinese men, with the most severe effects in those with moderate to high fever, researchers from Sichuan Provincial Maternity and Child Health Care Hospital report in Scientific Reports. 

The researchers tracked semen quality in 58 men for up to 109 days after COVID-19 diagnosis and used a linear mixed-effects model to analyze semen parameters at different time points before and after infection. They noted that previous studies suggest that angiotensin-converting enzyme 2 (ACE2) facilitates SARS-CoV-2 entry into testicular cells, where it leads to testes injury and impairs sperm production.

Higher fever, worse impact

While there was no significant difference in semen volume before or after COVID-19 diagnosis, median total sperm count and concentration were lower after infection. Total sperm motility and progressive motility were significantly lower after diagnosis, and the percentage of non-moving sperm was higher. 

Rates of sperm survival and normal sperm form decreased, with greater head defects but similar numbers of sperm with neck, mid-piece, or tail defects. No differences were noted in the number of round cells, anti-sperm antibodies, semen liquefaction time, or viscosity before or after COVID-19 infection.

Fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible.

The greatest drop in sperm count and concentration occurred within 30 days, followed by a gradual recovery and normalization by 90 days. The percentage of normal sperm fell, and the percentage of sperm with head defects significantly increased from 30 to 60 days, followed by recovery. An initial drop in sperm survival returned to baseline by 30 days.

Patients with a moderate or high fever saw a statistically significant decline in semen parameters, while those with a mild fever did not.

"Fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible," the study authors concluded.

• Colombia has reported two Oropouche virus cases, the fourth country in the Americas to report cases of the disease this year, the Pan American Health Organization (PAHO) said in an epidemiologic update. The infections were detected via retrospective case-finding from 187 samples collected in 2024 by Colombia's National Health Institute as part of dengue surveillance. The patients are from Amazonas and Meta departments. Amazonas is in the far south, and Meta is the central region. The disease is spread by midges and some mosquito species. Bolivia, Brazil, and Peru have also reported cases this year. 
• Soligenix, a biopharmaceutical company based in New Jersey, recently announced that the US Food and Drug Administration (FDA) has granted orphan drug designation to the active ingredient in SuVax, its subunit protein recombinant vaccine as prevention and postexposure prophylaxis against Ebola Sudan, for which no vaccines or treatments currently exist. Ebola Sudan is the second most common cause of human Ebola infections. In 2022, Uganda experienced an Ebola Sudan outbreak that resulted in 164 cases, 55 of them fatal. Earlier this year, the company reported that a bivalent (two-strain) version of the vaccine in a nonhuman primate trial provided complete protection against Ebola Sudan and Marburg viruses.