The cases in Malawi bring the number of African countries affected by mpox to 23.
Tests on respiratory samples were negative, but results were positive for the cerebrospinal fluid sample.
Only about a quarter of survey respondents knew H5N1 can spread to people, and over half were unaware that pasteurized milk is safer than raw milk.
No poultry outbreaks were reported in the patient's state, but there were detections in wild birds.
Complex Pandemic Accord negotiations have been under way since 2021, with 13 formal meetings and numerous informal sessions.
The patients are from three different provinces, two of them children and one of them a 35-year-old woman.
In other H5N1 developments, the WHO releases surveillance guidance for human cases, and the USDA announces new funding to mitigate livestock diseases.
A 3-year-old girl from Mexico recently hospitalized with H5N1 avian flu has died from her infection.
Newly affected herds are from Nevada and California.
Though no recent poultry outbreaks were reported in that part of Mexico, there were some detections in wild birds.
