The buck was harvested near the border with Michigan, where CWD had already been detected.
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In other CWD developments, Minnesota's agriculture department released safety tips for meat processors who handle deer.
The deer, found in the north-central lower peninsula, showed symptoms including wasting, drooling, and lack of fear of people.
Such actions include boosting research capacity, expanding hunting seasons, offering more hunting permits, and restricting baiting.
Nine deer farms in the state are still operating after a CWD detection, and 17 were previously shut down after deer tested positive.
Since 2013, Iowa officials have confirmed 260 cases of chronic wasting disease in 16 counties.
Data on chronic wasting disease sampling in Wyoming's large game animals for 2022 suggests a slow rise, with the disease spreading from east to west.
A month after Oklahoma reported its first CWD case in a wild deer, another white-tailed deer has tested positive, this time in Woodward County.
The DNR aims to focus restrictions on areas at greatest risk for the spread of chronic wasting disease.
Florida's first CWD case has been detected in a road-killed deer in the Panhandle and has prompted nearby states to take action.
The disease was found in a targeted male mule deer near Rock Springs in the west central part of the state.