"Look what happened—Delta showed up a month from now, relative to a year ago, and then Omicron. In a way, we're still in that kind of world. We don't know yet what the next variant or variants will be."

"We've never seen this subvariant activity with Alpha, Beta, or Delta, so who could have predicted 6 months ago where we'd be at? That's the challenge we have."

"Should the FDA approve the [COVID] vaccine for younger than age 5, the data we have right now suggests that [parents are] going to wait. It is still a huge challenge in terms of getting our kids vaccinated. Converting a vaccine into a vaccination is really difficult in this age group."

“If you do just look at those friends, colleagues, neighbors who are infected—confirmed by a home test or a PCR test—it is remarkable how many people are infected right now."

“I think it [the recent unexplained pediatric hepatitis cases] could be a very difficult nut to crack."

"The idea that you're modeling six months out? It's pixie dust. Six months ago we didn't have Omicron,"

"I've seen no data which supports the possibility of a fall or winter surge in the US resulting in 100 million cases. No one should make that kind of statement without providing the assumptions behind that number. Could it happen? Sure, but it's more likely if a new variant shows up that is more infectious and more likely to evade existing immune protection than Omicron. Any modeling that looks beyond 30 days out is largely based on pixie dust."

“There is one way [to slow the rate of evolving variants], and it’s to stop transmission. If the virus is not reproducing itself, we wouldn’t see nearly the same level of mutational changes.”

"It's impossible to predict what will happen," next in the pandemic.

“I don't know what the next shoe is to drop. I don't know. It could be this is as bad as it's gonna get, from here on out, much more mild illness if you have any immunity at all. Or maybe it won't be. I don't know.”

"Everybody is worried about omicron, which is understandable. I am worried about what is going to be pi or sigma or whatever is next."

“Any time you’re dealing with H5N1, you sleep with one eye open."

"Every day is a brand new day with this pandemic, relative to the variants. We know that we have strains that are much more infectious, so that, you know, you can't come up with an answer today to say this is where we're at because tomorrow, it could change."

“Public health advice has been way off the mark, all along, about mask protection. We have given the public a sense of a level of protection that is just not warranted. Let’s just be honest.”

“This virus is so highly infectious that you don’t need to have a lot of exposure to get infected. These variants are 210-mile-per-hour curveballs. What’s going to happen is really in the hands of the virus.”

“Now, we need to know, more than ever before, what’s going on out there. Meanwhile, it’s getting harder and harder to get testing done."

"One challenge we have with this virus is that we are going to continue to be bombarded by new variants, because this virus changes much faster than the flu. We have to expect the unexpected and, if we don't, we will end up being a day late and a dollar short."

The current reported 95% rate of asymptomatic COVID-19 cases in Shanghai, China, "just does not make any biologic sense at all. At this point, I just challenge the authenticity of data."

“We’re not gonna be able to boost our way out of this."

“I don’t know, and I don’t think anybody really knows" why new US COVID-19 cases haven't begun to rise amid Omicron BA.2 subvariant dominance.