A review of 600 US patients treated for suspected sepsis found 32% most likely didn't have a bacterial infection, while nearly 80% with a bacterial infection received overly broad antibiotics.
Researchers find no association between SEP-1 compliance and mortality after adjusting for factors related to noncompliant care.
Stewardship interventions in 2 neonatal intensive care units were associated with reduced antibiotic use in newborns with culture-negative sepsis.
A systematic review and meta-analysis found no high- or moderate-level evidence that compliance with SEP-1 was associated with a mortality benefit.
AstraDx will receive $3 million to develop a test that detects and identifies pathogens and analyzes antimicrobial susceptibility in whole blood drawn from newborns.
In critically ill sepsis patients treated at UK hospitals, a daily PCT-guided protocol reduced antibiotic duration safely compared with standard care.
Among more than 124,000 US sepsis patients who had no resistant organisms through day 4 of hospitalization, antibiotics were de-escalated in less than 30%.
The study found that viruses and tropical diseases were more significant causes of sepsis in India than previously known.
A review and meta-analysis found that the pooled prevalence of carbapenem resistance in bacteria from newborns with suspected sepsis in Africa was 30.4%.
The new test can cut the time to treatment from 2 or 3 days to about 13 hours, the authors say.
